Identification of monomorphic and polymorphic genes associated with recessive fertility defects in Holstein cows reared in Kazakhstan
نویسندگان
چکیده
Haplotypes of candidate genes namely: apoptotic protease activating factor 1 (APAF1 p.Q579X or HH1), glycinamide ribonucleotide formyltransferase (GART HH4), structural maintenance chromosomes 2 (SMC2 HH3), and haplotype cholesterol deficiency (HCD) associated with recessive fertility defects (loss fertility) were investigated in imported Canadian Holstein cows reared at “Medeu Commerce” LLP breeding farm Kazakhstan. The genotypic profiling the APAF1/HH1, GART/HH4 carriers was carried out by PCR-RFLP methods using BstC8I Tru9I MseI, while SMC2/HH3, HCD our own primer designed internal marker methods. study revealed that diagnostic markers APAF1/HH1 for monomorphic investigated. However, SMC2/HH3 (our design markers) polymorphic, frequencies 3% 11%, respectively, cows. concluded genetic monitoring enables timely identification harmful lethal mutations, control elimination process.
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ژورنال
عنوان ژورنال: Veterinarski Arhiv
سال: 2022
ISSN: ['0372-5480', '1331-8055']
DOI: https://doi.org/10.24099/vet.arhiv.139